Cell cycle non-specific drugs:  • Alkylating agents (FMGE Dec 2020) • Platinum compounds  Alkylating agents Drugs Nitrogen mustard • Mechlorethamine (Mustin chloride) • Cyclophosphamide • Melphalan • Cholrambucil • Busulfan Nitrosoureas Bifunctional alkylating agents Miscellaneous • Temozolomide • Dacarbazine • Procarbazine • Thiotepa • Altretamine • Trabectedin • Lubinectedin  Platinum compounds- • Cisplatin • Carboplatin • Oxaliplatin • Nedaplatin Platinum-induced nephropathy: • Platinum compounds cause direct toxicity to proximal tubule (S3 segment), leads to acute tubular necrosis (ATN). […]