|
Drug name |
Mechanism of action |
Bacterio static/cidal |
Side effects |
|
Isoniazid (INH) |
Inhibits synthesis of mycolic acid in the mycobacterial cell wall |
Bactericidal |
Hepatitis Peripheral neuropathy |
|
Rifampin (RIF) |
Inhibits DNA-dependent RNA polymerase |
Bactericidal |
Hepatotoxicity Orange-red discoloration of body fluids Gastrointestinal disturbances |
|
Pyrazinamide (PZA) |
Disrupts mycobacterial cell membrane metabolism and transport functions |
Bactericidal |
Hepatotoxicity Hyperuricemia (gout) Arthralgia (joint pain) |
|
Ethambutol (EMB) |
Inhibits arabinosyl transferase, affecting cell wall synthesis |
Bacteriostatic |
Optic neuritis (visual disturbances) |
|
Streptomycin |
Inhibits protein synthesis by binding to the 30S ribosomal subunit |
Bactericidal |
Ototoxicity (hearing loss) Vestibular toxicity Nephrotoxicity |
