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Apoptosis

Pathology
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Group

Examples

Role in Apoptosis

Anti Apoptotic

• BCL2

• BCL-XL

• MCL1

Prevent apoptosis by inhibiting the release
of apoptogenic factors from the mitochondria,
such as cytochrome c.

Pro Apoptotic

• BAX

• BAK

Promote apoptosis by facilitating the release
of cytochrome c and activating caspases.

Sensors

• BAD

• BIM

• BID

• Puma

• Noxa

• Detect cellular stress and damage

• Regulate the balance between pro- and
anti-apoptotic signals.

 

Pro apoptotic genes- 

• BAX (Bcl-2-associated X protein)

• BAK (Bcl-2 antagonist killer)

 

Anti Apoptotic genes- 

• BCL-2 (B-cell lymphoma 2)

• BCL-XL (BCL-2-like protein 1) 

• MCL-1 (Myeloid cell leukemia sequence 1) 

• FLIP (FLICE-like inhibitory protein) 

 

Sensors- 

• BAD 

• BIM

• BID

• Puma

• Noxa