|
DNA damaging agents |
DNA lesions |
DNA Repair Mechanism |
Related Diseases |
|
• Ionizing radiation • X-rays • Anti tumour drugs |
• Double / Single strand breaks • Intra strand crosslink |
Homologous Repair (HR) |
• AT-like disorder (ATLD) • Bloom syndrome • Breast cancer (BRCA 1 & 2 mutations) • Nijmegen breakage syndrome (NBS) • Werner syndrome • Rothmund-Thomson syndrome (RTS) |
|
• UV rays • Chemicals |
• Bulky adducts • Pyrimidine dimers |
DNA Nucleotide Excision Repair (NER) |
• Xeroderma pigmentosum (XP) • Cockayne syndrome (CS) • Trichothiodystrophy (TTD) |
|
• Oxygen radicals • Hydrolysis • Alkylating agents |
• Abasic sites • Single strand breaks • 8-oxoguanine lesions |
DNA Base Excision Repair (BER) |
• MUTYH-associated polyposis (MAP) |
|
• Replication error |
• Base mismatch • Insertion • Deletion |
DNA Mismatch Repair (MMR) |
• Lynch syndrome (Hereditary nonpolyposis colorectal cancer, HNPCC) |
Defective Homologous Repair (HR)-
1. AT-like disorder (ATLD)
2. Bloom syndrome (BS)
3. Breast cancer susceptibility 1 & 2 (BRCA 1 & 2)
4. Nijmegen breakage syndrome (NBS)
5. Werner syndrome
6. Rothmund-Thomson syndrome (NBS)
Defective Non-homologous End Joining (NHEJ)-
1. Severe combined immunodeficiency (SCID)
2. Radiation sensitive SCID (RS-SCID)