Complex I inhibitors-
1. Rotenone
2. Amobarbital (Barbiturates)
3. Piericidin A
Complex ll inhibitors-
1. TTFA (Thenoyl tri fluoro acetone)
2. Carboxin
3. Malonate
Complex III inhibitors-
1. Antimycin A
2. BAL
Complex IV Inhibitors- prevents the reduction of oxygen to water
1. CO (Carbon monoxide oxide)
2. CN (Cyanide)
3. H2S (Hydrogen sulfide) / Sewer gas
Oxidative phosphorylation inhibitors
|
Inhibitors |
Target |
Mechanism of action |
|
Oligomycin (Antibiotic) |
ATP synthase (Complex V) |
Blocks ATP synthase by binding to its Fo subunit, preventing proton flow |
|
Atractyloside (Plant toxin) |
Adenine nucleotide translocator (ANT) |
Inhibits ATP synthesis by stopping ADP/ATP exchange |