Kidney syndrome | Primary affected site | Channel | Genetics | Acidosis / alkalosis |
Fanconi syndrome | Proximal convoluted tubule (PCT) | - | - | Metabolic acidosis |
Bartter syndrome | Thick ascending loop of henle (TAL) | Na-K-2Cl | Autosomal recessive | Metabolic alkalosis |
Gitelman’s syndrome | Distal convoluted tubule (DCT) | Thiazide sensitive NCCT (Na-Cl cotransporter) | Autosomal recessive | Metabolic alkalosis |
Liddle syndrome | Collecting duct (CD) | ENaC (Epithelial sodium channel) | Autosomal dominant | Metabolic alkalosis |
Fanconi syndrome | Bartter syndrome | Gitelman syndrome | Liddle syndrome |
Proximal convoluted tubule (PCT) | Thick ascending loop of henle (TAL) | Distal convoluted tubule (DCT) | Collecting duct (CD) |
- | Na-K-2Cl | Thiazide sensitive NCCT (Na-Cl cotransporter) | Gain of function of ENaC (Epithelial sodium channel) |
- | Autosomal recessive | Autosomal recessive | Autosomal dominant (AD) |
Metabolic acidosis | Metabolic alkalosis | Metabolic alkalosis | Metabolic alkalosis |