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Alkylating agents & Platinum compounds
Cell cycle non-specific drugs: • Alkylating agents (FMGE Dec 2020) • Platinum compounds Alkylating agents Drugs Nitrogen mustard • Mechlorethamine (Mustin chloride) • Cyclophosphamide • Melphalan • Cholrambucil • Busulfan Nitrosoureas Bifunctional alkylating agents Miscellaneous • Temozolomide • Dacarbazine • Procarbazine • Thiotepa • Altretamine • Trabectedin • Lubinectedin Platinum compounds- • Cisplatin • Carboplatin • Oxaliplatin • Nedaplatin Platinum-induced nephropathy: • Platinum compounds cause direct toxicity to proximal tubule (S3 segment), leads to acute tubular necrosis (ATN). […]
Important questionnaire in psychiatry
Questionnaire Use for M-CHAT (Modified Checklist for Autismin Toddlers) Autism spectrumdisorders SCOFF (Sick, Control, One, Fat, Food) Eating disorderINI-CET May 2023 CAGE (Cut, Annoyed, Guilty, and Eye) Alcoholism https://youtu.be/6ma322K04u4?si=Mmc9FLXD4npJGlHK Forensic Medicine and Toxicology Test for semen By TCML March 6, 2026 No Comments
GABA- A, B, C receptor
Feature GABA-A GABA-B GABA-C Type Ionotropic Metabotropic (GPCR) Ionotropic Channel Type Cl⁻ (chloride) channel Cl⁻ influx G-protein coupled: Gi type(indirectly opens K⁺ channels) K⁺ efflux Cl⁻ (chloride) channel Action Fast inhibitory Slow & prolonged inhibitory Slow inhibitory Subunits Pentameric (2α, 2β, γ) Dimer of GABA-B1 & GABA-B2 subunits Pentameric (mostly ρ subunits) Location Brain […]
Surfactant
Lung surfactant is a lipoprotein substance that lines the inner surface of the alveoli in the lungs. Composition: • Dipalmitoylphosphatidylcholine (DPPC) / Lecithin – Main component • Surfactant proteins: SP-A, SP-B, SP-C, SP-D • Cholesterol • Phosphatidyl glycerol Surfactant protein B (SP-B): • SP-B helps DPPC spread evenly over the alveolar surface. • Deficiency of SP-B leads to neonatal pulmonary alveolar proteinosis (PAP). Functions: • Reduces surface tension in alveoli […]
Vitamin B3 (Niacin)
Vitamin B3 (Niacin) deficiency-🔴 See in Maize / corn earters (Mnemonic: M is looking like 3)M = 3Maize = B3 🟡 Symptoms: (Mnemonic: 3D in B3)– Diarrhea – Dermatitis: Casal collar– Dementia https://youtu.be/UGHioYFlH90?si=4gxgtJK56q-UF0re Forensic Medicine and Toxicology Test for semen By TCML March 6, 2026 No Comments Anaesthesia Capnography By TCML March 1, 2026 No […]