TCML

INI CET Application Form 2026 (Released) for July Session

Anatomy Ansa cervicalis By TCML March 28, 2026 No Comments Pharmacology SGLUT 2 inhibitor By TCML March 19, 2026 No Comments Obstetrics and Gynecology, Pediatrics Antenatal Corticosteroid Therapy By TCML March 15, 2026 Comments Disabled Physiology Laplace’s law By TCML March 13, 2026 Comments Disabled Medicine ABCD² Score for TIA By TCML March 12, 2026 […]

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Ansa cervicalis

The ansa cervicalis is a loop of nerves in the neck that supplies most of the infrahyoid (strap) muscles. Formation- It is formed by two roots: 1. Superior root (descendens hypoglossi) • Fibers from C1 spinal nerve • Travel briefly with the hypoglossal nerve (CN XII) 2. Inferior root (descendens cervicalis) • Fibers from C2

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SGLUT 2 inhibitor

SGLUT-2 inhibitors: Act on kidney– Cana gliflozin– Dapa gliflozin 🌴 MOA-Block SGLU-2 in PCT → Decrease glucose reabsorption → more glucose excreted in urine, lowering blood sugar levels. 🟡 S/E- SGLT2 inhibitors make glucose pass into urine → urine becomes sugar-rich → bacteria grow easily → ↑ risk of UTI (and fungal infections). 🚨 SGLUT-2

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Laplace’s law

Laplace’s Law describes the relationship between pressure, surface tension, and radius in curved surfaces like bubbles, blood vessels, or alveoli in the lungs. For a spherical structure For a cylindrical structure P = 2T / r P = pressure inside the sphere (alveoli) T = surface tension r = radius of the sphere P =

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Alkylating agents & Platinum compounds

Cell cycle non-specific drugs:  • Alkylating agents (FMGE Dec 2020) • Platinum compounds  Alkylating agents Drugs Nitrogen mustard • Mechlorethamine (Mustin chloride) • Cyclophosphamide • Melphalan • Cholrambucil • Busulfan Nitrosoureas Bifunctional alkylating agents Miscellaneous • Temozolomide • Dacarbazine • Procarbazine • Thiotepa • Altretamine • Trabectedin • Lubinectedin  Platinum compounds- • Cisplatin • Carboplatin • Oxaliplatin • Nedaplatin Platinum-induced nephropathy: • Platinum compounds cause direct toxicity to proximal tubule (S3 segment), leads to acute tubular necrosis (ATN).

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