Parameter | Dual Test | Triple Test | Quadruple Test |
Timing | First trimester | Second trimester | Second trimester |
Components | 1. Beta-hCG 2. PAPP-A • Nuchal translucency | 1. Beta-hCG 2. AFP 3. uE3 | 1. Beta-hCG 2. AFP 3. uE3 4. Inhibin A |
*PAPP-A (Pregnancy associated plasma protein-A)
Edwards syndrome, Down syndrome and NTD (Neural tube defect)-
HCG | uE3 | MSAFP | |
Trisomy 18 (Edward syndrome) | Low | Low | Low |
Trisomy 21 (Down’s syndrome) | High | Low | Low |
Neural tube defect | – | – | High |
• In down’s syndrome – High hCG, Low PAPP-A
