Uncouplers of ETC | Uncouplers matlab engine chal raha hai but gaadi aage nahi badh rahi — heat hi heat! 🔥😄
Uncouplers are chemicals that disconnect (uncouple) electron transport from ATP synthesis.
Normally:
ETC → pumps H⁺ → forms proton gradient → ATP synthase makes ATP
With uncouplers:
– They destroy the proton gradient by allowing H⁺ ions to leak back into the matrix without passing through ATP synthase.
– ETC runs faster, consuming more oxygen.
– ATP production drops.
– Energy is released as heat (non shivering thermogenesis)
Physiological uncouplers | Chemical uncouplers |
• Thyroxine • Thermogenin (Uncoupling protein 1; UCP-1): found in brown adipose tissue • Long chain fatty acid | • 2, 4 – DNP (Di nitro phenol) • Di nitro cresol • FCCP (Fluoro carbonyl cyanide phenyl hydrazine) • Asprin (in high dose) |
