Shift | Right Shift | Left Shift |
Affection for oxygen | Decreased affinity | Increased affinity |
Hb-oxygen binding | Oxygen is less tightly bound; more readily released | Oxygen is more tightly bound; less readily released |
Causes | – Increased CO2 | – Decreased CO2 |
– Increased temperature | – Decreased temperature | |
– Decreased pH (acidosis) | – Increased pH (alkalosis) | |
– Increased 2,3-BPG | – Decreased 2,-BPG | |
Implication | Enhanced oxygen delivery to tissues | Reduced oxygen delivery to tissues |
Oxygen-hemoglobin dissociation curve
Shift | Right Shift | Left Shift |
Affection for oxygen | Decreased affinity | Increased affinity |
Hb-oxygen binding | Oxygen is less tightly bound; more readily released | Oxygen is more tightly bound; less readily released |
Causes | – Increased CO2 | – Decreased CO2 |
– Increased temperature | – Decreased temperature | |
– Decreased pH (acidosis) | – Increased pH (alkalosis) | |
– Increased 2,3-BPG | – Decreased 2,-BPG | |
Implication | Enhanced oxygen delivery to tissues | Reduced oxygen delivery to tissues |
